Chelsea will host Shrewsbury or Liverpool, while Bournemouth can set up a south coast derby with Portsmouth if they beat Arsenal in Monday’s game.
Wayne Rooney could face his former side Manchester United in the fifth round of the FA Cup if Derby can beat Northampton in their fourth-round replay.
All eight ties will be played across three midweek nights from 3-5 March.
More to follow.
FA Cup fifth-round draw
Sheffield Wednesday v Manchester City
Reading or Cardiff City v Sheffield United
Chelsea v Shrewsbury Town or Liverpool
West Bromwich Albion v Newcastle United or Oxford United
Leicester City v Coventry City or Birmingham City
Northampton Town or Derby County v Manchester United
Southampton or Tottenham Hotspur v Norwich City
Portsmouth v Bournemouth or Arsenal
