The Trump administration has carried out its 13th federal execution since July – the most of any presidency in more than 100 years.
Dustin Higgs was convicted of murdering three women in a Maryland wildlife refuge in 1996.
The 48-year-old was the third inmate to receive a lethal injection at the federal prison in Terre Haute, Indiana, this week.
He was pronounced dead at 1.23am local time (6.23am UK time) on Saturday.
The justice department resumed federal executions last year following a 17-year hiatus.
No president in more than 120 years has overseen as many federal executions.
Not since the waning days of Grover Cleveland’s presidency in the late 1800s has the US government executed federal inmates during a presidential transition, according to the Death Penalty Information Centre.
