Manchester United will meet Spanish side Sevilla in the quarter-finals of the Europa League after seeing off another Spanish opposition, Retis Betis 5-1.
In the other last-eight ties, Roma face Feyenoord and Bayer Leverkusen meet Union Saint-Gilloise.
The first legs take place on 13 April, with the return games on 20 April.
Sevilla defeated Erik ten Hag’s Manchester United in the semi-finals on their way to winning it in 2020.
Should they advance, Erik ten Hag’s side will face either Juventus – whose squad includes former United midfielder Paul Pogba – or Arsenal’s conquerors Sporting Lisbon in the semi-finals.
Their squad includes Brazil defender Alex Telles, who is on loan from United.
“Sevilla are very experienced in the Europa League and have won it so many times,” said United boss Ten Hag.
“We have to be aware of it.”
Ten Hag’s side, who won last month’s Carabao Cup, are also still in the FA Cup and host Fulham in the quarter-finals of that competition on Sunday (16:30 GMT).
Europa League quarter-final draw
Manchester United v Sevilla
Juventus v Sporting Lisbon
Bayer Leverkusen v Union Saint-Gilloise
Feyenoord v Roma
