Isco scored twice as a scintillating Spain beat Italy at the Bernabeu to take a huge step towards qualifying for the World Cup from Group G.
The Real Madrid playmaker curled home a free-kick and then smashed in a second as Spain named no recognised striker.
Chelsea’s Alvaro Morata came on to add a third from Sergio Ramos’ cross.
Italy, who had not lost a qualifier since 2004, trail Spain by three points with a much worse goal difference and are likely to be in the play-offs.
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📺 ¿Cuántas veces quieres ver el GOLAZO de @isco_alarcon? #VamosEspaña pic.twitter.com/akLr5uyfci
— Selección Española (@SeFutbol) September 2, 2017
Only the winners of each group qualify directly for Russia, with the eight best ranked second-placed teams playing off.
The Azzurri are still four points above third-placed Albania, who beat Liechtenstein 2-0.
Macedonia beat Israel 1-0 in the group’s other match.
Ukraine are top of Group I following a 2-0 win over Turkey, new Borussia Dortmund striker Andriy Yarmolenko scoring both goals.
Croatia, who are one point behind them, have a game in hand – after their match with Kosovo was abandoned at 0-0 in the first half because of a waterlogged pitch. No new date for that game has been set.
Iceland, behind Croatia on goal difference, lost 1-0 to Finland.