France lost 3-1 to Italy at the San Siro in the Nations League, their first defeat under Zinedine Zidane.
Les Bleus went ahead when Italy goalkeeper Gianluigi Donnarumma played the ball straight to Michael Olise, who got past a couple of defenders before firing it in.
However, Roberto Mancini’s side drew level through Pio Esposito’s clever near-post finish from a Nicolo Cambiaghi ball.
Sebastiano Esposito missed a penalty for Italy before Davide Frattesi, set up by Federico Dimarco, smashed in a second.
The Azzurri were awarded another penalty, which Pio Esposito converted to claim his second goal.
The 21-year-old Inter Milan striker has now scored nine goals in his first 14 caps.
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It was the first time Italy had beaten France in a home game since 1962.
Zidane, the former France captain and ex-Real Madrid manager, took over from Didier Deschamps after the World Cup and had guided them to three wins and a draw.
Italy now sits at the top of Group A1, ahead of France on a better head-to-head record.
The two teams are level on 10 points, one above Belgium, who came from behind to beat Turkey 2-1 earlier.
The top two sides will progress to the quarter-finals. In Sunday’s final group games, Belgium hosts Italy while France welcomes Turkey.
