Philippe Coutinho’s sublime pass on the half-hour mark cut open the Hammers defence and picked out an unmarked Sturridge who went around goalkeeper Adrian before slotting home.
The Brazilian then scored two of his own after the break before Divock Origi fired in a fourth to complete the Liverpool procession.
Victory against Middlesbrough on the final day of the season will guarantee Liverpool a Champions League place in 2017-18.
There were chances for both sides in a frenetic opening but as both teams settled in the London sun, it was Liverpool’s Brazilian magician who turned up the gears and once again orchestrated a Liverpool victory.
Sturridge, starting for the first time since January, christened his return with a goal as Liverpool dominated possession throughout.
West Ham endured a testing afternoon with Andre Ayew missing the easiest of chances at 1-0, before being left frustrated by some calamitous defending and a refereeing decision.
It was an unhappy end to their first season at London Stadium as the home supporters flooded the exits before the final whistle and left the players to do their lap of honour in front of empty seats.
Red hot Liverpool
The playmaker produced an exquisite pass from behind the halfway line for the opener as Sturridge evaded the offside trap and rolled home a tidy finish.
And after the break it was the Brazilian who once again turned up the heat.
Georginio Wijnaldum’s thunderbolt pinged back off the bar and Coutinho was the first to pounce before driving home to after a quick Liverpool counter-attack.
The Hammers woes were compounded when goalkeeper Adrian flapped at a high ball and Origi drilled in a fourth.
